Ireland v Italy has become the second women's game to fall victim to the ongoing risks around the coronavirus with the game due to be played in Dublin next week, called off.
Scotland's game against Italy was also called off last weekend - both games are currently listed as postponed - due to the lockdown of parts of northern Italy.
The decision to call off the Ireland game came after the IRFU held talks with Ireland's Minster for Health SImon Harries.
In a statement following the meeting, the IRFU said the National Public Health Emergency team had determined that all of the games against Italy - men's, women's and U20s, should not proceed, in the interests of public health.
It said it hoped to try to reschedule the match and would provide an update in the coming days.
With two games now having been cancelled involving Italy - and with England's away game surely hanging in the balance in the last round, refixing the games will be a logistical headache but with World Cup qualifiers to come later this year then sides like Italy will be desperate to get more games under their belt.